Publications

Preprints

2024

Gaining Insights into the Autistic Inner-experience Through a Personalized Digital Lens

2024

Peer Reviewed

Autism Autonomy Chapter 9 – Conclusions
Autism Autonomy Chapter 8 - The future generation got this
Autism Autonomy Chapter 7 - Building autonomy to regain our agency in science
Autism Autonomy Chapter 6 - Autistic adults
Autism Autonomy Chapter 5 - The autistic experience revealed through digital phenotyping
Autism Autonomy Chapter 4 - Screening and diagnosing autism
Autism Autonomy Chapter 3 - How babies attain volitional control
Autism Autonomy Chapter 2 - From Pavlov to Skinner to applied behavioral analyses: In search of a new cognitive revolution using AI, open data science, and machine learning
Autism Autonomy Chapter 1 - Introduction: The super systems and human neurodevelopment
Digital Screener of Socio-Motor Agency Balancing Autonomy and Control
Irregularity of instantaneous gamma frequency in the motor control network characterize visuomotor and proprioceptive information processing
J Neural Eng.
Infants on the move: bibiliometric analyses of observational vs. digital means of screening infant development
Front. Integr. Neurosci. 17.1251252

2023

The time is ripe for the renaissance of autism treatments
Front. Integr. Neurosci. 17:1229110
Exploring Cardiac Responses of Pain and Distress
IntechOpen - Recent Topics in Autonomic Nervous System
Sensing Echoes: Temporal misalignment as the Earliest Marker of Neurodevelopmental Derailment
PNAS Nexus, Volume 2, Issue 2, February 2023, pgac315

2022

Connecting Movement and Cognition Through Different Modes of Learning
Chapter in The Psychology of Learning and Motivation, Academic Press, Elsevier 2022 Vol 76
Dynamic Interrogation of Stochastic Transcriptome Trajectories Using Disease Associated Genes Reveals Distinct Origins of Neurological and Psychiatric Disorders
Front. Neurosci. 2022 16:884707
Editorial for Special Issue “Precision Medicine in Neurodevelopmental Disorders: Personalized Characterization of Autism from Molecules to Behavior”
MDPI Journal of Personalized Medicine J. Pers. Med. 2022, 12(6), 918
Motor Signatures in Digitized Cognitive and Memory Tests Enhances Characterization of Parkinson’s Disease
MDPI Sensors 2022, 22(12), 4434; https://doi.org/10.3390/s22124434
Toward Interpretable Digital Biomarkers of Walking and Reaching in Parkinson's Disease
Wearable Technologies 2022, Cambridge University Press, Volume 3, 2022, e21; https://doi.org/10.1017/wtc.2022.16
Precision Medicine in Neurodevelopmental Disorders: Personalized Characterization of Autism from Molecules to Behavior
MDPI Book 2022 - Open Access Printable Book; https://doi.org/10.3390/books978-3-0365-5128-9
Editorial for Research Topic Insights in Integrative Neuroscience 2021
Editorial: Women in neuroscience
Rethinking Statistical Learning as a Dynamic Stochastic Process, from The Motor Systems Perspective

2021

Stochastic characterization of EEG signals during the lingering sensation of discomfort evoked by temperature results in the perception of pain. This perception fundamentally differs in stochastic signature: Participants with over responsivity to pain produce EEG signals well characterized symmetric distributions amenable to sustain a memory-buffer predicting the impending pain-related events. Healthy controls show a memoryless exponential distribution that cannot predict impending pain-related events. They do not perceive the same stimulus as painful.

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify Its “Epidemic Rates”
J. Pers. Med. 2021, 11(11), 1119
Optimal Time Lags from Causal Prediction Model Help Stratify and Forecast Nervous System Pathology
Scientific Reports volume 11, Article number: 20904 (2021)
Personalized Biometrics of Physical Pain Agree with Psychophysics by Participants with Sensory over Responsivity
J. Pers. Med. 2021, 11(2), 93
Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
J. Vis. Exp. (171), e61943

2020

Videos

Department Colloquium For Torres Full Professorship Featuring Autism Research Program

Peer Reviewed Articles

Cover Story: The data from digitized social interactions can take us beyond the limits of the naked eye and help us capture the autistic capacity for social readiness. Using personalized analytics, we can track the person’s dynamics with biosensors that continuously co-register the micro-movements derived from their biorhythms. More important yet, we can track the spontaneously self-emerging cohesiveness of their social rapport and better inform our decisions on whether and when the socio-motor patterns of autistic people unexpectedly match those of neurotypical controls performing the same social task. Our new unifying statistical methods help us bridge the enormous social gap that current diagnostics, missing this information, have created between autistic and neurotypical people.

Aging with Autism Departs Greatly from Typical Aging
Sensors 2020, 20(2), 572;
Digitized ADOS: Social Interactions Beyond the Limits of the Naked Eye
Journal of Personalized Medicine - MDPI
Reframing Psychiatry for Precision Medicine
Journal of Personalized Medicine - MDPI
The Autonomic Nervous System Differentiates Between Levels of Motor Intent and End Effector
Journal of Personalized Medicine - MDPI
Sensory-Motor Aspects of Nervous Systems Disorders: Insights from Biosensors and smart technology in the dynamic assessment of disorders, their progression, and treatment outcomes
e-Book Frontiers in Integrative Neuroscience
Hidden Aspects of the Research ADOS are Bound to Affect Autism Science

Neural Computation

Traditional Autism Diagnostics currently driving and informing Autism Science are statistically flawed. These flawed criteria would never help people on the spectrum become an integral part of our society. They need a total revamp.

[Video] Digital ADOS in simple words

2019

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson’s Disease
JoVE
Proceedings of the Fourth International Conference on Movement Computing
MOCO '19 Association for Computing Machinery
Dance from the heart

2018

Chapter 1 - The Closed Feedback Loops Between the Peripheral and the Central Nervous Systems, the Principle of Reafference and Its Contribution to the Definition of the Self
Elsevier Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders
Chapter 2 - Critical Ingredients for Proper Social Interactions: Rethinking the Mirror Neuron System Theory
Elsevier Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders
Chapter 3 - The Case of Autism Spectrum Disorders: When One Cannot Properly Feel the Body and Its Motions From the Start of Life
Elsevier Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders
Chapter 4 - The Case of Schizophrenia: Is that My Arm Moving on Purpose or Spontaneously Passing by?
Elsevier Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders
Chapter 5 - Learning to Detect Expertise in Sports Aided by the Gift of Our Students
Elsevier Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders
Chapter 6 - Rethinking Diagnoses and Treatments of Disorders
Elsevier Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders
Chapter 7 - Different Biometrics for Clinical Trials That Measure Volitional Control
Elsevier Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders
Chapter 8 - Adding Dynamics to the Principle of Reafference: Recursive Stochastic Feedback Closed Control Loops to Evoke Autonomy
Elsevier Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders
Peripheral Network Connectivity Analyses for the Real-Time Tracking of Coupled Bodies in Motion
Sensors - MDPI
Autism Research: An Objective Quantitative Review of Progress and Focus Between 1994 and 2015
Frontiers in Psychology
Statistical Platform for Individualized Behavioral Analyses Using Biophysical Micro-Movement Spikes
Sensors - MDPI
Characterization of noise signatures of involuntary head motion in the Autism Brain Imaging Data Exchange repository
Frontiers in Integrative Neuroscience
A biomarker characterizing Neurodevelopment with applications to autism
Nature Scientific Reports
Characterization of Sensory-Motor Behavior Under Cognitive Load Using a New Statistical Platform for Studies of Embodied Cognition
Frontiers in Human Neuroscience

2017

Stochastic signatures of involuntary head micro-movements can be used to classify females of ABIDE into different subtypes of neurodevelopmental disorders
Frontiers in Integrative Neuroscience
The social-dance: Decomposing Naturalistic dyadic interaction dynamics to the micro-level
Proceedings of the Fourth International Conference on Movement Computing, MOCO '17 Association for Computing Machinery
Methods for Tracking Dynamically Coupled Brain-Body Activities during Natural Movement
Proceedings of the Fourth International Conference on Movement Computing, MOCO '17 Association for Computing Machinery
Section I Chapter 1, Why study movement variability in autism
BOOK CHAPTER - Neuroscience Series, Autism: The Movement Sensing Approach. CRC Press, Taylor and Francis, Elizabeth B Torres and Caroline P Wyatt (editors)
Concluding Remarks to Section I - Top-Down vs Bottom-Up Approaches to Connect Cognition and Somatic Motor Sensations
BOOK CHAPTER - Neuroscience Series, Autism: The Movement Sensing Approach. CRC Press, Taylor and Francis, Elizabeth B Torres and Caroline P Wyatt (editors)
Section II Chapter 4, Dissecting a social encounter from three different perspectives
BOOK CHAPTER - Neuroscience Series, Autism: The Movement Sensing Approach. CRC Press, Taylor and Francis, Elizabeth B Torres and Caroline P Wyatt (editors)
Section II Chapter 7, ADOS: The Physiology approach to assess social skills and communication in Autism Spectrum Disorder
BOOK CHAPTER - Neuroscience Series, Autism: The Movement Sensing Approach. CRC Press, Taylor and Francis, Elizabeth B Torres and Caroline P Wyatt (editors)
Preface to Section III - First Things First, Let us Get the Math Right
BOOK CHAPTER - Neuroscience Series, Autism: The Movement Sensing Approach. CRC Press, Taylor and Francis, Elizabeth B Torres and Caroline P Wyatt (editors)
Section III Chapter 14, Micro-Movements: The s-Spikes as a way to zoom-in the motor trajectories of natural goal-directed behaviors
BOOK CHAPTER - Neuroscience Series, Autism: The Movement Sensing Approach. CRC Press, Taylor and Francis, Elizabeth B Torres and Caroline P Wyatt (editors)
Section III Chapter 13, Contemporary problems with methods in basic brain science impede progress in ASD research and treatments
BOOK CHAPTER - Neuroscience Series, Autism: The Movement Sensing Approach. CRC Press, Taylor and Francis, Elizabeth B Torres and Caroline P Wyatt (editors)
Section III Chapter 4, Inherent noise hidden in nervous systems rhythms leads to new strategies for detection and treatments of core motor-sensing traits in ASD
BOOK CHAPTER - Neuroscience Series, Autism: The Movement Sensing Approach. CRC Press, Taylor and Francis, Elizabeth B Torres and Caroline P Wyatt (editors)
Section IV Chapter 27, Turning the Tables - Autism Shows the Social Deficit of Our Society
BOOK CHAPTER - Neuroscience Series, Autism: The Movement Sensing Approach. CRC Press, Taylor and Francis, Elizabeth B Torres and Caroline P Wyatt (editors)
Concluding remarks to Section IV
BOOK CHAPTER - Neuroscience Series, Autism: The Movement Sensing Approach. CRC Press, Taylor and Francis, Elizabeth B Torres and Caroline P Wyatt (editors)
Conclusions
BOOK CHAPTER - Neuroscience Series, Autism: The Movement Sensing Approach. CRC Press, Taylor and Francis, Elizabeth B Torres and Caroline P Wyatt (editors)

2016

Neonatal Diagnostics: Towards Dynamic Growth Charts of Neuromotor Control
Frontiers in Pediatrics Child Care and Human Development
Motor Noise is Rich Signal in Autism Research and Pharmacological Treatments
Nature Scientific Reports
Characterization of the statistical signatures of micro-movements underlying natural gait patterns in children with Phelan McDermid syndrome: Towards precision-phenotyping of behavior in ASD
Frontiers in Integrative Neuroscience
Outcome Measures of Deliberate and Spontaneous Motions
Proceedings of the Third International Conference on Movement Computing , MOCO '16 , Thessaloniki, Greece Association for Computing Machinery
Schizophrenia: The Micro-movements perspective
Neuropsychologia
Towards Precision Psychiatry: Statistical Platform for the Personalized Characterization of Natural Behaviors
Frontiers in Neurology
Automatically Characterizing Sensory-motor Patterns Underlying Reach-to-Grasp Movement on a Physical Depth Inversion Illusion
Frontiers in Human Neuroscience
Rethinking the Study of Volition for Clinical Use
Springer BOOK CHAPTER Progress in Motor Control, Jozsef Lazcko and Mark Latash (editors)

2015

Objective and Personalized Longitudinal Assessment of a Pregnant Patient with Post Severe Brain Trauma
Frontiers in Human Neuroscience
Behavioral Inflexibility and Motor Dedifferentiation in Persons with Parkinson's Disease: Bilateral Coordination Deficits During a Unimanual Reaching Task
Neuroscience Letters

2014

Motor Output Variability, Deafferentation and Putative Deficits in Kinesthetic Reafference in Parkinson's Disease
Frontiers in Human Neuroscience
Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior
JoVE
Micro-Movements as Physical Signature of Movement Intention in Work of Choreographer Myriam Gourfink
Proceedings of the First International Conference on Movement Computing, MOCO '14 Paris, France Association for Computing Machinery

2013

Intentional Signal in Prefrontal Cortex Generalizes Across Different Sensory Modalities
Journal of Neurophysiology
Spatial Orientation-Priming Impedes Rather than Facilitates the Spontaneous Control of Hand-Retraction Speeds in Patients with Parkinson's Disease
PLoS ONE
Strategies to Develop Putative Biomarkers to Characterize the Female Phenotype with Autism Spectrum Disorders
Journal of Neurophysiology
Neural Correlates of Learning and Trajectory Planning in the Posterior Parietal Cortex
Frontiers in Integrative Neuroscience
The Rates of Change of the Stochastic Trajectories of Acceleration Variability are a Good Predictor of Normal Aging and of the Stage of Parkinson's Disease
Frontiers in Integrative Neuroscience
Noise from the Periphery in Autism
Frontiers in Integrative Neuroscience
Give Spontaneity and Self-discovery a Chance in ASD: Spontaneous Peripheral Limb Variability as a Proxy to Evoke Centrally Driven Intentional Acts
Frontiers in Integrative Neuroscience
Autism: The Micro-Movements Perspective
Frontiers in Integrative Neuroscience
Editorial for Research Topic “Autism: the Movement Perspective”
Frontiers in Integrative Neuroscience
Cognitive Load Results in Motor Overflow in Essential Tremor
Neurocase
Signatures of Movement Variability Anticipate Hand Speed According to Levels of Intent
Behavioral and Brain Functions - Springer

2012

Atypical Signatures of Motor Variability Found in an Individual with ASD
Neurocase

2011

Two Classes of Movement in Motor Control
Experimental Brain Research
Impaired Endogenously Evoked Automated Reaching in Parkinson's Disease
Journal of Neuroscience

2010

New Symmetry of Intended Curved Reaches
Behavioral and Brain Functions
Sensory-Spatial Transformations in The Left Posterior Parietal Cortex May Contribute to Reach Timing
Journal of Neurophysiology

2002-2009

From Multiple Neural Cortical Networks to Motor Mechanical Behavior: The Importance of Inherent Learning Over Separable Space-Time Length Scales
BioMed Central
Computing Movement Geometry: A Step in Sensory-Motor Transformations
Elsevier, Prog Brain Res Computational Motor Control, Editor Paul Cisek, 2007
Space-Time Separation During Obstacle-Avoidance Learning in Monkeys
Journal of Neurophysiology, 2006
Simultaneous Control of Hand Displacements and Rotations in Orientation-Matching Experiments
Journal of Applied Physiology, 2004 (with a Commentary)
Reaching to Grasp With a Multi-Jointed Arm (I) Computational Model
Journal of Neurophysiology, 2002